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I didn't think we could cure this
condition, but I now do.

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Congenital Melanocytic Naevi
is lots and lots of big moles.

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We see patients with enormous birthmarks

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up to 80% of their body surface area.

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And they often have many different problems
in the rest of their body as well.

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We've been pursuing
principally silencing RNA therapies.

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What I thought might happen
maybe five years ago, I was thinking

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it's good, we're managing to target this.

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Maybe we'll be able to dial it down

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and we'll have a treatment
that we can put on once a week.

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Maybe it'll make things a bit better.

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But actually probably about four years ago

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I began to realise that it had a chance
that it may kill the cells.

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And sure enough, when we started
treating our cells in dishes

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with the siRNA, they die.

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That was definitely
beyond my wildest dreams.

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There is a possibility of curing this condition
and that for me is a game changer.