I didn't think we could cure this condition, but I now do.
Congenital Melanocytic Naevi is lots and lots of big moles.
We see patients with enormous birthmarks
up to 80% of their body surface area.
And they often have many different problems in the rest of their body as well.
We've been pursuing principally silencing RNA therapies.
What I thought might happen maybe five years ago, I was thinking
it's good, we're managing to target this.
Maybe we'll be able to dial it down
and we'll have a treatment that we can put on once a week.
Maybe it'll make things a bit better.
But actually probably about four years ago
I began to realise that it had a chance that it may kill the cells.
And sure enough, when we started treating our cells in dishes
with the siRNA, they die.
That was definitely beyond my wildest dreams.
There is a possibility of curing this condition and that for me is a game changer.